Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Phox2b  paired-like homeobox 2b   (Synonyms: Dilp1, GENA 269, NBPhox, Phox2b, Pmx2b, Px2b)
Results	Reference
1*	J:130196 Alfonsi F, Filippi P, Salaun D, deLapeyriere O, Durbec P, LIFR beta plays a major role in neuronal identity determination and glial differentiation in the mouse facial nucleus. Dev Biol. 2008 Jan 1;313(1):267-78
1	J:124919 Anderson RB, Turner KN, Nikonenko AG, Hemperly J, Schachner M, Young HM, The cell adhesion molecule l1 is required for chain migration of neural crest cells in the developing mouse gut. Gastroenterology. 2006 Apr;130(4):1221-32
1*	J:119681 Bates MD, Dunagan DT, Welch LC, Kaul A, Harvey RP, The Hlx homeobox transcription factor is required early in enteric nervous system development. BMC Dev Biol. 2006;6:33
1	J:230425 Bouilloux F, Thireau J, Venteo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigere F, Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016;5:e11627
1	J:182736 Bravo-Ambrosio A, Mastick G, Kaprielian Z, Motor axon exit from the mammalian spinal cord is controlled by the homeodomain protein Nkx2.9 via Robo-Slit signaling. Development. 2012 Apr;139(8):1435-46
1	J:138626 Callahan T, Young HM, Anderson RB, Enomoto H, Anderson CR, Development of satellite glia in mouse sympathetic ganglia: GDNF and GFRalpha1 are not essential. Glia. 2008 Oct;56(13):1428-37
1	J:162557 Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bevengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L, Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control. J Neurosci. 2010 Jul 14;30(28):9465-76
1	J:224198 Chen Y, Takano-Maruyama M, Fritzsch B, Gaufo GO, Hoxb1 controls anteroposterior identity of vestibular projection neurons. PLoS One. 2012;7(4):e34762
1*	J:174215 Chen Y, Takano-Maruyama M, Gaufo GO, Plasticity of neural crest-placode interaction in the developing visceral nervous system. Dev Dyn. 2011 Aug;240(8):1880-8
1	J:213171 Cheng L, Desai J, Miranda CJ, Duncan JS, Qiu W, Nugent AA, Kolpak AL, Wu CC, Drokhlyansky E, Delisle MM, Chan WM, Wei Y, Propst F, Reck-Peterson SL, Fritzsch B, Engle EC, Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling. Neuron. 2014 Apr 16;82(2):334-49
1	J:166770 Coppola E, d'Autreaux F, Rijli FM, Brunet JF, Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development. 2010 Dec;137(24):4211-20
1	J:157532 Coppola E, Rallu M, Richard J, Dufour S, Riethmacher D, Guillemot F, Goridis C, Brunet JF, Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2066-71
1	J:180432 D'Autreaux F, Coppola E, Hirsch MR, Birchmeier C, Brunet JF, Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20018-23
1*	J:86516 Dauger S, Pattyn A, Lofaso F, Gaultier C, Goridis C, Gallego J, Brunet JF, Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways. Development. 2003 Dec;130(26):6635-42
1	J:314904 Dempsey B, Sungeelee S, Bokiniec P, Chettouh Z, Diem S, Autran S, Harrell ER, Poulet JFA, Birchmeier C, Carey H, Genovesio A, McMullan S, Goridis C, Fortin G, Brunet JF, A medullary centre for lapping in mice. Nat Commun. 2021 Nov 2;12(1):6307
1	J:217450 Dias JM, Alekseenko Z, Applequist JM, Ericson J, Tgfbeta signaling regulates temporal neurogenesis and potency of neural stem cells in the CNS. Neuron. 2014 Dec 3;84(5):927-39
1	J:85552 Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, Deneris E, Johnson RL, Chen ZF, Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci. 2003 Sep;6(9):933-8
1	J:211702 Dyachuk V, Furlan A, Shahidi MK, Giovenco M, Kaukua N, Konstantinidou C, Pachnis V, Memic F, Marklund U, Muller T, Birchmeier C, Fried K, Ernfors P, Adameyko I, Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors. Science. 2014 Jul 4;345(6192):82-7
1	J:196818 Espana A, Clotman F, Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. Mol Cell Neurosci. 2012 May;50(1):93-102
1	J:253866 Espinosa-Medina I, Jevans B, Boismoreau F, Chettouh Z, Enomoto H, Muller T, Birchmeier C, Burns AJ, Brunet JF, Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11980-11985
1	J:249229 Espinosa-Medina I, Outin E, Picard CA, Chettouh Z, Dymecki S, Consalez GG, Coppola E, Brunet JF, Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Science. 2014 Jul 4;345(6192):87-90
1	J:237201 Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F, Richardson WD, Brunet JF, The sacral autonomic outflow is sympathetic. Science. 2016 Nov 18;354(6314):893-897
1	J:116626 Flynn B, Bergner AJ, Turner KN, Young HM, Anderson RB, Effect of Gdnf haploinsufficiency on rate of migration and number of enteric neural crest-derived cells. Dev Dyn. 2007 Jan;236(1):134-41
1	J:244596 Furlan A, Dyachuk V, Kastriti ME, Calvo-Enrique L, Abdo H, Hadjab S, Chontorotzea T, Akkuratova N, Usoskin D, Kamenev D, Petersen J, Sunadome K, Memic F, Marklund U, Fried K, Topilko P, Lallemend F, Kharchenko PV, Ernfors P, Adameyko I, Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science. 2017 Jul 07;357(6346)
1*	J:65599 Gaufo GO, Flodby P, Capecchi MR, Hoxb1 controls effectors of sonic hedgehog and mash1 signaling pathways. Development. 2000 Dec;127(24):5343-54
1	J:86041 Gaufo GO, Thomas KR, Capecchi MR, Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons. Development. 2003 Nov;130(21):5191-201
1	J:88581 Gaufo GO, Wu S, Capecchi MR, Contribution of Hox genes to the diversity of the hindbrain sensory system. Development. 2004 Mar;131(6):1259-66
1	J:86070 Grillet N, Dubreuil V, Dufour HD, Brunet JF, Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b. J Neurosci. 2003 Nov 19;23(33):10613-21
1	J:269168 Hernandez-Miranda LR, Ibrahim DM, Ruffault PL, Larrosa M, Balueva K, Muller T, Weerd W, Stolte-Dijkstra I, Hostra RMW, Brunet JF, Fortin G, Mundlos S, Birchmeier C, Mutation in LBX1/Lbx1 precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13021-13026
1	J:138599 Hong SJ, Lardaro T, Oh MS, Huh Y, Ding Y, Kang UJ, Kirfel J, Buettner R, Kim KS, Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta. J Biol Chem. 2008 Jun 13;283(24):16860-7
1	J:199593 Huber K, Narasimhan P, Shtukmaster S, Pfeifer D, Evans SM, Sun Y, The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells. Dev Biol. 2013 Aug 15;380(2):286-98
1	J:231591 Iskusnykh IY, Steshina EY, Chizhikov VV, Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei. J Neurosci. 2016 Mar 2;36(9):2691-710
1	J:128441 Jacob J, Ferri AL, Milton C, Prin F, Pla P, Lin W, Gavalas A, Ang SL, Briscoe J, Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci. 2007 Nov;10(11):1433-9
1	J:257400 Kim KT, Kim N, Kim HK, Lee H, Gruner HN, Gergics P, Park C, Mastick GS, Park HC, Song MR, ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons. Sci Rep. 2016 Nov 7;6:36491
1	J:122604 Morikawa Y, D'Autreaux F, Gershon MD, Cserjesi P, Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol. 2007 Jul 1;307(1):114-26
1	J:86051 Muller M, Jabs N, Lork DE, Fritzsch B, Sander M, Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons. Development. 2003 Dec;130(23):5815-26
1	J:199284 Munoz-Bravo JL, Hidalgo-Figueroa M, Pascual A, Lopez-Barneo J, Leal-Cerro A, Cano DA, GDNF is required for neural colonization of the pancreas. Development. 2013 Sep;140(17):3669-79
1	J:190742 Nagashimada M, Ohta H, Li C, Nakao K, Uesaka T, Brunet JF, Amiel J, Trochet D, Wakayama T, Enomoto H, Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression. J Clin Invest. 2012 Sep 4;122(9):3145-58
1	J:295953 Niu X, Liu L, Wang T, Chuan X, Yu Q, Du M, Gu Y, Wang L, Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo. J Neurosci. 2020 Aug 26;40(35):6691-6708
1	J:331513 Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ, Dysregulation of locus coeruleus development in congenital central hypoventilation syndrome. Acta Neuropathol. 2015 Aug;130(2):171-83
1*	J:110707 Pattyn A, Guillemot F, Brunet JF, Delays in neuronal differentiation in Mash1/Ascl1 mutants. Dev Biol. 2006 Jul 1;295(1):67-75
1*	J:43772 Pattyn A, Morin X, Cremer H, Goridis C, Brunet JF, Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development. 1997 Oct;124(20):4065-75
1	J:91076 Pattyn A, Simplicio N, van Doorninck JH, Goridis C, Guillemot F, Brunet JF, Ascl1/Mash1 is required for the development of central serotonergic neurons. Nat Neurosci. 2004 Jun;7(6):589-95
1	J:82563 Pattyn A, Vallstedt A, Dias JM, Samad OA, Krumlauf R, Rijli FM, Brunet JF, Ericson J, Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Genes Dev. 2003 Mar 15;17(6):729-37
1	J:157923 Potzner MR, Tsarovina K, Binder E, Penzo-Mendez A, Lefebvre V, Rohrer H, Wegner M, Sock E, Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Development. 2010 Mar;137(5):775-84
1	J:72062 Qian Y, Fritzsch B, Shirasawa S, Chen CL, Choi Y, Ma Q, Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev. 2001 Oct 1;15(19):2533-45
1	J:76655 Qian Y, Shirasawa S, Chen CL, Cheng L, Ma Q, Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1. Genes Dev. 2002 May 15;16(10):1220-33
1	J:124186 Rebelo S, Reguenga C, Osorio L, Pereira C, Lopes C, Lima D, DRG11 immunohistochemical expression during embryonic development in the mouse. Dev Dyn. 2007 Sep;236(9):2653-60
1	J:338174 Reiprich S, Stolt CC, Schreiner S, Parlato R, Wegner M, SoxE proteins are differentially required in mouse adrenal gland development. Mol Biol Cell. 2008 Apr;19(4):1575-86
1	J:155760 Rose MF, Ren J, Ahmad KA, Chao HT, Klisch TJ, Flora A, Greer JJ, Zoghbi HY, Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009 Nov 12;64(3):341-54
1	J:314775 Sagner A, Zhang I, Watson T, Lazaro J, Melchionda M, Briscoe J, A shared transcriptional code orchestrates temporal patterning of the central nervous system. PLoS Biol. 2021 Nov;19(11):e3001450
1	J:185348 Saito D, Takase Y, Murai H, Takahashi Y, The dorsal aorta initiates a molecular cascade that instructs sympatho-adrenal specification. Science. 2012 Jun 22;336(6088):1578-81
1	J:142435 Shi M, Guo C, Dai JX, Ding YQ, DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain. Mol Cell Neurosci. 2008 Dec;39(4):529-38
1	J:119655 Song MR, Shirasaki R, Cai CL, Ruiz EC, Evans SM, Lee SK, Pfaff SL, T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development. 2006 Dec;133(24):4945-55
1	J:143526 Storm R, Cholewa-Waclaw J, Reuter K, Brohl D, Sieber M, Treier M, Muller T, Birchmeier C, The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei. Development. 2009 Jan;136(2):295-305
1*	J:324832 Sun Y, Wang L, Zhu T, Wu B, Wang G, Luo Z, Li C, Wei W, Liu Z, Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep. 2022 Mar 22;38(12):110542
1*	J:158122 Takano-Maruyama M, Chen Y, Gaufo GO, Placodal sensory ganglia coordinate the formation of the cranial visceral motor pathway. Dev Dyn. 2010 Apr;239(4):1155-61
1*	J:179737 Takano-Maruyama M, Chen Y, Gaufo GO, Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior-posterior axis. Dev Dyn. 2012 Feb;241(2):229-41
1	J:91470 Theriault FM, Roy P, Stifani S, AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10343-8
1	J:344101 Tsimpos P, Desiderio S, Cabochette P, Poelvoorde P, Kricha S, Vanhamme L, Poulard C, Bellefroid EJ, Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage. Neural Dev. 2024 Jan 2;19(1):1
1	J:343072 Vermeiren S, Cabochette P, Dannawi M, Desiderio S, San Jose AS, Achouri Y, Kricha S, Sitte M, Salinas-Riester G, Vanhollebeke B, Brunet JF, Bellefroid EJ, Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. iScience. 2023 Dec 15;26(12):108364
1	J:106244 Yan H, Bergner AJ, Enomoto H, Milbrandt J, Newgreen DF, Young HM, Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol. 2004 Aug 1;272(1):118-33
1	J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247